However, here we are concerned only with effects of toxins on the skin. A variety of skin conditions can arise from exposure to toxic substances. Contact dermatitis or inflammation of the skin can be of two types, irritant dermatitis and allergic contact dermatitis. The basic inflammatory reaction is the same but the cause and progress of the dermatitis differs.

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Normally, the contact dermatitis is reversible if the irritant or allergen is removed. The more common form of hemotoxicity results from chemicals acting directly on the hematopoietic tissues (blood-forming tissue). The primary effect is a decrease in formation of specific blood cells so that the number in the circulating blood is reduced, impairing their ability to function normally. For example, phenothiazine and anticonvulsant drugs can damage the bone marrow cells that give rise to the granuloctyes and decreased ability to fight infections.

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With irritant dermatitis the effect is immediate without prior exposure, whereas the allergic dermatitis requires previous exposure with the development of allergy or sensitization. Contact dermatitis is common in industry and usually consists of redness , thickening and firmness of skin , flaking , and blisters .

Aspirin and nitroglycerin can be toxic to megakaryocytes that produce blood platelets. Other toxins, e.g. , arsenic, benzene, and chlordane, can cause a decrease in the formation of all blood elements, a condition known as aplastic anemia.

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Cancer of the hematopoietic tissues also occurs due to exposure to some industrial chemicals and drugs,for example, benzene, chloramphenicol, and phenylbutazone. The HCS definition for hepatotoxins is «chemicals which produce liver damage». Signs of hepatotoxicity may include jaundice and liver enlargement. Hepatotoxicity includes not only the liver but also the gallbladder and bile duct. The liver is particularly susceptible to foreign chemicals because of its large blood supply and the major role it plays in metabolism.

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